A.B.
I have been on the Dep shot and thought it was basicaly the cat's meow. I did not gain weight (obesity is common in my family) and I also stopped having monthly periods. Because of the absolute omission of a period, I would go in 10 days late for every other shot to allow my perod to occur. My guess is that each woman will be different in how their body regulates with the Dep shot though. Consider that the suggested weight gain while posibly true, may be caused in part by a placedo effect. They say its supposed to happen so it does.