E.S.
I have the Skip Hop Studio Tote (http://www.skiphop.com/product/21500.html), and I love it. It has many specialized compartments and can be zipped up completely.
I also have the Skip Hop Duo Deluxe bag (http://www.skiphop.com/product/20000.html) for days when my husband and I are both going to be carrying the bag. This one is a little smaller but is also a great bag.
I bought both online with coupon codes, so I didn't have to pay full price for neither of them.