We tried Destin with my son and it burned him even worse. Poor thing used to get those leather-appearing, butt peeling rashes due to medications and severe diarrhea.
One of the daycare workers suggested Balmex for my little guy and it cleared up that rash in about 3 days with constant use..every time we changed we would cover his little bum with that stuff.
He is now 8 yrs old but still has sensitive skin and eczema once in a while.
Give your wee one a good soak in the tub and use a wash cloth with no soap to clean with. Try to avoid baby wipes and if possible give his skin some nothing but air time :0) Use a onesie or pants to help control the "accidents" if any.
Good luck!
J. S.