M.P.
I would start with getting him used to being with people he knows while you're away. He is at the age where it's normal to have this sort of separation anxiety. And so he may scream when you leave but he'll probably calm down soon after. Do this over and over until he's used to being left with this person(s).
Leave him with a person who is able to spend time with him to distract him from your absence. Perhaps provide a favorite toy. Definitely take his blankie or whatever "lovey" he relies on for comfort.
Be sure to express confidence in his ability to handle the situation. Do not linger or try to calm him. Make leaving him a matter of fact, this is the way we live sort of experience. It's no big deal to you attitude even tho you know it is to him and thus to you.