My daughter is 2 1/2 and we struggle at times, but for the most part, we can brush them, or she does it, twice a day without too much trouble. We have a couple of toothbrushes to choose from, even our own...I don't care if she uses mine, as long as she is brushing. (We do however toss them all in the dishwasher everyonce in a while) We then give her a choice between white toothpaste or blue, or both if she so chooses. Then, we use the "Buggies" idea. We say, "I see a buggie on your teeth, you better get him." That gets her excited and she chases him around in her mouth with the toothbrush. Sometimes they're easy to catch, and sometimes they're fast, and sometimes, they are hiding behind a tooth, or they jump from tooth to tooth, those ones we call hoppers. Then, she finally catches him on the toothbrush and rinses him down the sink. We say she is a good bug catcher. She loves it and then, we smell her breath. This sounds really gross, but we have found that it works. We tell her that her breath smells beautiful and it doesn't smell like buggie poopoo anymore. I think she knows there isn't a bug or poopoo in her mouth, because she'll go along with the game and even point to her toothbrush and say, "There he is!" and nothing is there, so we know she knows it's a pretend game by now, but it's a little game we can do to start and end our day. She goes along with it without too much fuss. If you want to use this technique, I'd suggest a little chat about germs and bugs and how they make us sick and are on our shoes, hands, butts, mouth, etc. Then, that same night,...surprise her with..."Oh my gosh! I see a buggie in your teeth...you better fish him out with your toothbrush. YUK!" That'll get her attention and she'll maybe start fishing around with her brush. Then, enourage her like she's winning a race. "Get him...he's fast, Get him." She'll be hooked. At least my daughter was. Good luck!