Our doctor said to let her lay down, close her eyes, put several drops in the corner of the eye by the nose, and let her blink a bunch of time. You can then rub the remaining liquid in the corner over her closed eyelid along the edge. We did one eye at a time and had her head tilted a little with pillow to create a little "well" near the nose where some drops would stray. We were able to finish the treatment with 1 bottle, but if necessary I would have spent money on a second bottle to avoid the fight. Our eyedoctor assistant (for the dilating drops) has the kids lay back on her chair, and then close their eyes, and she very quickly pulls the lids towards the eyebrow with a flat finger and with the other hand whips a drop into the eyes. I have tried it that way but was not successful. Good luck. Make sure she and you wash hands a lot since pink eye is extremely contagious. Also do not use that same dropper bottle for anyone but her.