A.W.
I'd recruit your 10 yr old to be a parent helper. I did that when I took care of my neice and nephew a couple of years ago (4 kids total - 10, 7, 4, 2) The older kids got dressed first then took over with the younger ones (washing faces and making sure teeth were brushed) while I finished getting myself ready. I told each child that the washcloth they used in the morning to wash their face would also be used that night for their bath; which helped keep the laundry load down a little. On the weekends, I'd recommend going out and being active in the AM so your little ones get a little worn out and nap after lunch. In the afternoon, playing in the yard would be enough. Also, what about doing a craft project? You could do simple Thanksgiving or Christmas ones.
You mentioned that you work from home. Are your younger children home with you too? If so, you may want to hire someone to come in and help with the younger ones.
As for meals, I try to plan ahead, freeze what I can, and have leftovers. It really helps on the days when my family and I feel like we're being pulled all over the place.
I'm sure the time will fly by!