YES! My son was the same way with clothing and NO it does not mean there is anything wrong with your child (I thought the same thing when he first started with all the clothing issues at around 3 years old). I do know that sometimes it means there is something else going on medically, so to be sure you should of course speak to your ped about it, but in my sons case there was nothing else wrong, he simply liked to be comfortable.
When I gave up trying to get him into cute outfits and let him be, we stopped having fights in the morning before school. We had one REALLY bad incident when he was asked to be a ring bearer in a wedding and getting him in the clothes the day of was a nightmare. He finally agreed to put them on and then he started to hyperventilate he was so upset about how uncomfortable he was. He also would not participate in karate when he was 4 because they insisted he had to wear the stiff uniform – no matter how many times I washed it to soften it, he would put on the pants but didn’t’ like the idea of tying on the belt. People suggested to us that he might have OCD or Autism.
He is now 7, still wears what he calls "fluffy" or "comfy" clothes - no jeans, or button down shirts (but for special occasions he can now "suffer" thought it). Our Dr. said it's more of a control thing, particularly when they can't button or zipper themselves yet but even though at this age he can of course manipulate the button/zips, he still likes to be comfortable and will pull off his socks/shirt as soon as he walks in the door.
We worked with it like anything else you teach your children and stopped making a big deal of it. We explained that at home you can wear what you want (drives my MIL crazy she says he’s never dressed- LOL). He know that we will do our best to let him go MOST places in comfy clothes, but sometimes we will need him to dress appropriately (i.e., for a wedding) and we aren't against bribing if necessary ;-). He now wears the karate uniform because he REALLY wanted to join. He also LOVES skiing but didn't want to wear all the gear - guess what??!! He "suffers" though it because it’s for something he likes to do - so we think the Dr is right that it's a control issue - hey, kids are told what to do in every aspect of their life I guess some figure this is one thing they can control ;-). Hope that helps settle your mind a bit that it might not mean it's a serious health problem. Good luck!
BTW – my son is a straight A student (is actually a bit bored with the curriculum at times), has a vocabulary that is way beyond his years, has tons of friends is very friendly with everyone he meets and is very well rounded taking cooking and sports classes and defiantly does NOT have OCD or even the slightest bit of autism. So MAYBE, just MAYBE these things mean that they are super smart NOT that they have a medical problem ;-) just trying to give you hope I know it’s very hard.