I would agree with Attitude is Everything! And If Mama Ain't Happy, Ain't Nobody Happy. So knowing and really understanding how much work and effort it takes to move is important.
Two years ago I went kicking and screaming from Southern California across the country. It took my Mom's commitment to me to come often and help me get settled that made the difference (we are very close and used to live very near each other). The truth is we have a much better life here now then we would have had if we stayed in California. At times I do still feel new here since I haven't found doctors I like or a mechanic or a good hairdresser or a reliable gardener, all part of my support network back in California. Also spontaneous childcare is very hard without nearby family or old friends, I still struggle with that one too.
If there is anyway to go to North Carolina or a nearby state there really is a value to being in driving distance to family. I believe one of the greatest gifts we can give our children is a relationship with their grandparents and cousins and one of the greatest gifts we can give our parents and siblings is a relationship with their grandchildren and nieces and nephews. It takes a lot more effort to be close to family. Cell phones and SKYPE have made a huge difference.
My last advice is to commit to your new life. If possible, don't rent buy a new house, make it your home, if you are renting you are less likely to feel like this new place is really yours. Find a church or synagogue early on in your new state, become a member and belong and get involved. The only way to meet people outside of your family is to get outside of your home.
If you are quiet and you sit and listen to your instincts often you know what you want to do. You posted this question so obviously you are thinking about it a lot. What does your gut tell you?
Good luck.