The main problem in today's economy is that employers have the luxury of being much more selective than they used to have to be.
I learned this the hard way when my company went through a massive downsizing last year. I was laid off, thought I had great/applicable skills, and had a hard time landing interviews. I was lucky to get back to work after 3 months but at 80% my previous base salary.
My job loss was in the pharmaceutical industry. Average applicants to 1 open position are currently at 300. Most recruiters have to "search" for keywords to identify suitable candidates.
From all I've read recently, cover letters are really important to help distinguish yourself from other candidates and to explain why you're the best choice to move forward with to an interview.
A few questions your husband is very likely to receive are:
1. Why did you leave the work force (easily explained by staying home with the kids)
2. Why he's looking at opportunities that require skills below what he left the workforce with? (also pretty easily explainable)
A lot of companies, though you hear you need to "know" someone, are moving to automated recruiting that doesn't give preference to someone having an inside contact.
I'd also recommend having him create a profile on professional networks such as Linkedin. The more exposure he can give himself by having his resume out there and by participating in discussions that are relevant to what he's trying to get into, the more likely he is to catch the attention of a potential employer.
Good luck. I hope the search ends quickly!