D.C.
My last trip to wine country, we stayed north of Sonoma in Healdsburg, CA at a bed and breakfast. It was great. We spent the days touring wineries in the Russian River Valley, Dry Creek Valley, and Sonoma. We stayed at the Hayden Street Inn, I recommend it.
And drive to the coast and have dinner in Jenner. The cliffs against the ocean are gorgeous.
We flew in to San Francisco, and drove up, spent 2 days touring wineries, then back to SF to come home.
Of course, this is only a good trip if you like wine, especially red wines. Lots of great zinfandels and pinot noirs. Also the Korbel estate, which is pretty commercial but a champagne tasting was fun.