S.F.
When we failed naturally to get pregnant my OB put us on Clomid along with a HCG shot to trigger ovulation. After 3 months of no success we went on to a reproductive encrindologist. He had us on Clomid also (but would adjust the dose), did the ultrasounds to see how I was responding, and also did the HCG shot. One side effect of continued use of Clomid is the growth of cysts which I had one cycle (it would not have been picked up without the ultrasound, and would have been a wasted cycle). I did not have any side effect (like moodiness) that you hear a lot of with Clomid. We also did IUIs but were unsuccessful on Clomid (although I responded very well, i.e. I made lots of follicles) and eventually went on to use a different type of fertility drug which is injected and that is how I had my twins! It is my understanding that the risk of multiples increase once you move on from Clomid, but of course it's always a possiblity. Best of luck!