J.B.
When I cook my brisket barbeque style, I put the brisket in a cooking bag (large bag but not turkey size) with plenty of salt and pepper and a bottle of KC Masterpiece barbeque sauce. I cook it on 250 degrees for about 6 to 8 hours. You could cook it overnight if you wanted too as this method really doesn't dry out the meat. Don't forget to puncture the bag in a couple of places near the tie though.
If you don't want the barbeque flavor, substitute the barbeque sauce for a 32 oz container of beef broth. Then also add a diced onion for flavoring.
Good luck.