I've used a generic for some years now. I don't think it does the greatest job but I tried to go off it and didn't do well. I've been able to reduce it to half dose, with my doctor's help and support, because I've added a nutritional supplement that helps me with better balance in my body, more energy, less illness, and so on. My cholesterol is lower, my sugars are good (so I don't get mood swings from that), my energy lets me work out more (so good endorphins are flowing). My doc is thrilled and wants to send me more of her patients who need the same help. The supplement is part of my grocery budget, I get it at a discount, and the company gave me phenomenal support by connecting me with others who had similar issues so I could figure out the best products to take, how much, how often, etc. That made all the difference. It didn't happen overnight but it happened. The supplement is all food, not drugs or chemicals, so it doesn't interfere with anything and it cuts my cravings for other foods - which in turn contributed to my depression. So I've been able to balance that chemical imbalance instead of just treat the symptoms. Same with all the people who helped me do it.
The new antidepressants that come out have had more studies - but those studies are generally funded by the companies that make the medication! So I question the objectivity. The doctors are visited regularly by the pharmaceutical reps who push these drugs. The companies make one small change when their patent runs out, then they apply for a new one, and they get 18 years to charge you top dollar to pay for their research and development. I don't mind paying for R&D if the product works...but if it's just treating the symptom, am I really improving things?
As for the specific generic that could help you if you take pills - I think it's very individual. I think it depends on what's going on in your body that has caused this imbalance to begin with. I am certain, from all my research, that it's based on digestion, intake of nutrients in a balanced way, absorption, and the quality of what we take in (which gets lower every year). You have already experimented with quite a few things and it's taken you a very long time and a lot of money. I pay $10 a month for my generic, and I've been able to cut it in half, so I buy 30 pills every other month. But I can only do this by supplementing nutritionally.