E.T.
Yup - I absolutely did. We had a 2800 sq foot house with garage and barn. No attic or basement. I took a weekend and went through EVERYTHING. I created one bin for each family member's sentimental stuff (baby clothes, awards, etc.) and three bins for holiday decorations. Everything else had to be in use or so pretty we loved looking at it - or else it was given away or sold. I got rid of almost 1,000 pounds of books, 20+ bags of clothes, and boxes and boxes of stuff that we didn't need... two boxes of kitchen utensils alone, plus three boxes of extra sheets and towels.
Best two days I've ever spent. I have empty shelves now, and cleaning the house takes about half the time. My life feels lighter and easier. Seriously, I recommend it.