After a lot of research, we went with the Honda Odyssey and have not regretted our decision. It provides a great smooth ride, great safety features, good finish and styling, and comes with better packages than the Sienna. We ended up getting the EX-L model. The only perks of the highest model, the Touring, is fog lights, an automated trunk, and more cup holders. Not worth it!
The Sienna was nice too, more comfortable ride, but the fit and finish was cheap and dull. Also, what turned us off was their packages; you had to spend so much more money just to get a navigation or heated outside mirrors. The Toyota dealers were not as friendly as the Honda dealers too.
The biggest things we love in our van is the rearview camera when you back up, the DVD/Navigation system, and the ease of folding down the seats and roomy interior.
Hondas go forever; many Hondas easily exceed 100,000 miles or more without any major trouble. You know you are getting a reliable car for a long time when you buy a Honda.