B.C.
They'll love the Maid of the Mist!
I'm not sure the Cave of the Winds would be good for their age - it can get a bit slippery.
Fort Niagara is on the American side of the river up where it flows into Lake Ontario - it's a lot of walking.
If you all have passports (they are required since about 5 yrs ago) be sure to visit the Canadian side - there's a lot more to do over there and the view of the falls really is better.
They have a great Butterfly Conservatory, a huge ferris wheel, a cable car ride out over the whirlpool, and Marineland is an all day thing - lot's of walking so rent a stroller (it'll seat 2).
If you're inclined to take the drive up to Toronto (roughly a 2 hr drive up there), they have African Lion Safari, the Toronto Zoo (it's huge - lot's of walking) and the Ontario Science Centere is always a lot of fun.
We've been up to visit family every few years and we'll be there again in a few weeks.