Many years ago, I took Tofranil for generalized anxiety/depression.
As far as I remember, it did work....
However... and this is what happened to me.... I ended up having a gran mal seizure from it.
I had been diagnosed with petit mal epilepsy as a child, but never took any medication for it... that is the one they sometimes say you "outgrow".....
Well, in my case, the Tofranil basically activated the latent epilepsy, and I then spent over 15 years on Tegretol. (I did stop taking it for a few months, then had another seizure.)
Tri-cyclic antidepressants (like Welbutrin and Tofranil) can lower seizure threshold, or activate latent epilepsy in a person that doesn't realize that they already have an abnormal EEG.
I did stop taking the Tegretol a few years ago, however, and have not had a seizure since. I also have not taken any anti-depressants or anxiety medications. (I've only had 2 gran mal seizures, though... and both were while taking some kind of medicine for anxiety/depression...once while taking Tofranil, and once while taking Buspar.)
I'm not saying they are bad, mind you.... you do have to be cautious any time you take a prescription medicine.
If I needed to take medication for anxiety/depression, I would take it, but be very cautious and probably go back on the Tegretol for possible seizure control.
I had even had in my records the seizure history, but the doctor didn't factor that into his decision on what medication to put me on.