Were on our 2nd T&C, our current one is 2006. Hubby is the main driver and he loves it. I like that it's very roomy and has a comfortable ride.
On the down side. Both of them have had issues with the brakes wearing out very quickly. Maybe it's just hubby's driving style, but at least 50% of the miles are highway. Also, both of them had problems with the sliding doors. Also, the first one started having issues arround 80,000 miles, so I wouldn't expect them to last much more than 100,000 without having to invest some money in repairs and maintenance.
Recently while having some regular maint. done, we took a look around the lot at the newer models. Hubby is all excited because the new models with all kinds of bells and whistles. I'm not impressed, as all the bells and whistles are things to make them luxery, things we don't need (i.e.heated steering wheel), and a hefty price tag to go along with it.