J.S.
My eldest daughter is left-handed and has never had any problems with any tech games or gadgets because of being left-handed. We've actually found that most things are being made in an "ambidextrous fashion" so that anyone regardless of their handedness can use it. Even child safety scissors are made this way now. I have a pair of adult scissors that are ambidextrous that I let her use since she's 11 years old that works really well for her. She even has the option on gadgets to set things up for her left-handedness if she wants to. I think her cell phone has this option, although I don't honestly know what the changes would be.
As for Leap systems, she never had any issues with them as they always seemed to accommodate for either handedness.