Your daughter is very young and zoloft is not a simple medication; it is widely overused in young children when behavioral methods do not seem to work, and parent's are at wits end for worry or sleeplessness. I understand your difficulty watching her SEEM to be anxious through her behaviors but this is NOT the same as a true anxiety disorder. At NIH there is now a huge body of evidence that some children are indeed born "anxious", but this is their nature not a psychological condition requiring medication. In the case that this is inborn personality and not an anxiety DISORDER (and there are huge differences in the two), it is not to be tampered with (i.e. that the child functions well in their important aspects of life albeit that all adults and older peers would DESCRIBE them an "anxious" in manner). Yes, they require little sleep, are often picky eaters, stand back from crowds or noise and can even appear jittery, but these are not sufficient reasons to change their natural state. It does make them more difficult to have in a household with other sibs---we know, we had one, and his early need for only about 4-5 hours of sleep per night regardless of our use of very consistent behavior modification nearly did us all in---and then there was the picky eating, problems with peer and social and school, but he seemed remarkably nonplussed in his early years and we were careful not to enhance his self-focus; even psych testing was described by us as something we all did so we did not create more of a problem by him thinking there was something wrong. Please seek advice from the head of the childhood anxiety program at NIH; he is amazingly astute and of course highly experienced. He also answers his own phone (!) and will return calls to parents with issues and questions. His name is Dr. Daniel Pine, considered the nation's current expert on childhood anxiety and use of pharmacology; his phone is at the end of this precis. http://intramural.nimh.nih.gov/research/pi/pi_pine_d.html I hope his wisdom assists in your daughter's case. You may be surprised at what you learn! Best wishes.